KULLIYYAH OF PHARMACY

KULLIYYAH OF PHARMACY

Research Groups

Research Groups



Background

Pharmacognosy is a science that focuses on molecules and involves isolation and determination of the structure of pharmacologically active molecules as well as the study of their biosynthesis, including the enzymes and the genes which are involved. It is extended to a big data analysis to connect between bioactivity, metabolites, and drug sources. Our current performance is indicated as follows. 


Scope of Research Activities

  1. Isolation and characterisation of bioactive compounds
  2. Metabolomics
  3. Bioactivity and toxicity studies
  4. Structure-activity relationship studies (SAR)
  5. Protein-ligand interaction studies
  6. Formulation of standardized extract 
  7. Extract enhancement
  8. Quality control


Leader and Members


Post Graduate Students (as Main Supervisor)

a. On-going (as main supervisor or chairman)

i. Ph.D students:

  • Hussam Abdeljaber Ahmed Mizher (G1524417). Thesis title: Investigation of opioids tolerance and its association with blood and cytokine concentration in the plasma of patients with non-cancer pain receiving short and long term opioid therapy for pain management. Chairman: Assoc. Prof. Dr. ABM Helal Uddin.
  • Nipun Tanzina Sharmin (G1710044). Thesis title: Evaluation of anti-diabetic activity of Psychotria malayana Jack leaves and characterization of its bioactive compounds using metabolomics and molecular docking simulation. Supervisor: Assoc. Prof. Dr. Alfi Khatib.
  • Hidayatul Radziah binti Ismawi (G1517424). Ph. D. Medical Science. (KOM). Thesis Title: Post Partum Endothelin – 1 (ET-1) and Hypertensive Disorders of Pregnancy. Supervisor: Assoc. Prof. Dr. A. B. M. Helal Uddin.
  • Mohammed S.M. Saleh (G152524). Thesis title: Phytochemical Profiling of Salak (Salacca Zalacca) Fruits Extracts through Metabolomics Approach and Investigations of their Antidiabetic and Antioxidant Potential In vitro, In silico and In vivo Studies. Supervisor: Asst. Prof. Mohammad Jamshed Siddiqui


ii. Master students:

  • Nur Nadhirah binti Hilmi (G1624744). Thesis Title: Comparison of Volatile Aroma Constituents of Salacca zalacca (Gaertn.) Voss Fruit Extracted by Conventional and Non-Conventional Methods. Supervisor: Assoc. Prof. Dr. Siti Zaiton.
  • Liyana Zafirah Binti Othman (G1623876). Thesis Title: Formulation and Analytical Method Development of Syariah Compliant Sustained Release Gliclazide Tablet. Supervisor: Assoc. Prof. Dr. ABM Helal Uddin.
  • Ahmed Nokhala (G1810281). Thesis Title: Evaluation of α- Glucosidase Inhibitory Activity o f Tetracera scandens Extracts using Metabolomics Approach. Supervisor: Asst. Prof. Mohammad Jamshed Siddiqui.


b. Graduated (as main supervisor or chairman)

i. Ph.D – no.of students:

  • Assoc. Prof. Dr. Siti Zaiton - 2
  • Assoc. Prof. Dr. Alfi Khatib - 2
  • Assoc. Prof. Dr. ABM Helal Uddin - 2
  • Assoc. Prof. Dr. Qamar Uddin Ahmed - 2


ii. Master – no.of students:

  • Assoc. Prof. Dr. Siti Zaiton - 2
  • Asst. Prof Dr. Norazian - 4
  • Assoc. Prof. Dr. Alfi - 2
  • Assoc. Prof. Dr. ABM Helal Uddin - 5
  • Assoc. Prof. Dr. Qamar Uddin Ahmed - 4
  • Asst Prof Dr Mohammad Jamshed - 1
  • Asst. Prof. Dr. Bisha Fathamah Uzir - 2
  • Asst. Prof. Dr. Irna Elina binti Ridzwan - 2


Laboratories and Facilities

a. Laboratories: Analytical and Bioanalytical Research Lab 1, Analytical Chemistry Research Lab 2, Analytical Chemistry Research Lab 3, Medicinal and Organic Chemistry Research Lab, Pharmaceutical Chemistry Lab 2, Tissue Culture Lab, Herbal Lab.

b. Facilities: FTIR, GCMS, Analytical and Preparative HPLC, AAS, UV-Vis


Link and Collaboration

  • MOU with Universitas Islam Indonesia,
  • MOU with Universitas Airlangga
  • MOU with International Medical University (IMU),
  • MOU with Cyberjaya University College of Medical Sciences (CUCMS)
  • MOU with UiTM


Community Services 

Education on Chemistry of Medicinal Plant – target group to IIUM community, government officers via e-buletin


Research Grant (as PI-on going)

  • RIGS16-293-0457. Isolation, Identification and Computational Studies of α-Glucosidase Inhibitors from Clinacanthus nutans (Burm F.) Lindau Leaves Extracts. Amount: RM 20,000.00. PI: Asst. Prof Dr. Zalikha Ibrahim.
  • SP17-002-0264. Analytical and Biological Activity Analysis of Malaysian leeches Saliva Extract of Both Green and Brown Types. BIOPEP Canada Inc. External Overseas grant. Amount :RM 70,000. PI: Assoc. Prof. Dr. A. B. M. Helal Uddin.
  • RIGS16-292-0456. Influence of multiple reaction monitoring (MRM) on the separation of amlodipine and perindopril in pharmaceutical dosage form and plasma..Amount: RM 20,000. PI: Assoc. Prof. Dr. A. B. M. Helal Uddin.
  • SP11-003-0071. Analytical method development for the detection and determination of amlodipine in pharmaceutical raw materials and dosage forms. Special fund from Ministry of Finance (MOF) Malaysia. Amount:RM 512,000. PI: Assoc. Prof. Dr. A. B.M. Helal Uddin.
  • RIGS15-090-0090. Addressing Formulation Issues of Syariah Compliant Generic Sustained Release Antidiabetic Solid Dosage Form. Co Researcher. IIUM Amount: RM 28,000. PI: Asst. Prof. Dr. Mohamed Sufian Bin Mohd Nawi.
  • P-RIGS18-027-0027. Identification of alpha-glucosidase inhibitors from P. malayana leaf extract using liquid chomatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking. Amount: RM 20,000. PI: Assoc. Prof. Dr. Alfi Khatib.
  • RIGS 15-099-0099. Isolation of Alpha-Glucosidase Inhibitor and aroma from the Flesh of Salak (Salacca zalacca) Fruit and Their Metabolic Profiling on GC/MS. Amount:20,000. PI: Asst. Prof. Dr. M. Jamshed Siddiqui.


List of Selected Publications (1 selected publication for 1 lecturer)

  • Opeyemi Roheem, Fatimah and Mat So'ad, Siti Zaiton and Ahmed, Qamar Uddin and Ali Shah, Syed Adnan and Latip, Jalifah and Zakaria, Zainul
  • Amiruddin (2019). Evaluation of the enzyme inhibitory and antioxidant activities of Entada spiralis stem bark and isolation of the active constituents. Molecules. ISSN 1420-3049
  • Md. Mahmudul Hasan, Qamar Uddin Ahmed, Siti Zaiton Mat Soad, Tasnuva Sarwar Tunna. (2018). Animal models and natural products to investigate in vivo and in vitro antidiabetic activity. Biomedicine & Pharmacotherapy Vol. 101: 833-841.
  • Muhamad Faris, O., Norazian, M. H., Alfi, K. & Siti Marponga, T. (2018). Antioxidant activities of Dialium indum L. fruit and gas chromatography-mass spectrometry (GC-MS) of the active fractions. Antioxidants, 7(11). 1-14. ISSN 2076-3921.
  • Murugesu, S., Ibrahim, Z., Qamar Uddin Ahmed, Uzir, B. F., Yusoff, N. I. N., Perumal, V., ... & Khatib, A. (2018). Identification of α-glucosidase inhibitors from Clinacanthus nutans leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking. Journal of Pharmaceutical Analysis (In Press).
  • Ibrahim, Z., Tejo, B. A., Latif, M. A. M., Karjiban, R. A., Salleh, A. B. and Rahman, M. B. A. (2016). In-silico Identification of Potential Protein Arginine Deiminase IV (PAD4) Inhibitors, Malaysian Journal of Analytical Sciences, 20 (6), 1269-1277.
  • A.B.M. Helal Uddin, Mohamed Alaama, Mohamed b. Awang and S.A. Abbas (2018). Development and Validation of Bioanalytical Method for the Analysis of Amlodipine in Human Plasma with Optimized Extraction Method Using Design of Experiment. Latin American Journal of Pharmacy. Lat. Am. J. Pharm. 37 (1): 99-104. (ISI)
  • Suganya Murugesu, Zalikha Ibrahim, Qamar Uddin Ahmed, Nik Mohd. Idris Nik Yusoff, Bisha Fathamah Uzir, Vikneswari Perumal, Faridah Abas, ...Hesham El-Seedi (2018). Characterization of αglucosidase inhibitors from clinacanthus nutans lindau Llaves by gas chromatography-mass spectrometry-based metabolomics and molecular docking simulation. Molecules, 23 (9). , 0 pp. 1-21. ISSN 1420-3049
  • Hariono, M., Choi, S. B., Roslim, R. F., Nawi, M. S., Tan, M. L., Kamarulzaman, E. E., Mohamed, N., Yusof, R., Othman, S., Rahman, N. A., Othman, R., Wahab, H. A. (2019). Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling. PLoS ONE, 14 (1). , 0 pp.  1 -21. ISSN 1932-6203.
  • Mohammed S M Saleh, Dzatil Awanis Mohd Bukhari, Mohammad Jamshed Ahmad Siddiqui, Abdul Razak Kasmuri, Suganya Murugesu, Alfi Khatib (2019). GC-MS analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of Salacca zalacca flesh and its alpha-glucosidase inhibitory activity. Natural Product Research. , 0 ISSN 1478-641926

Extraction and Isolation Laboratory






Background

Substance Use Disorder (SUD) is a growing public health problem that occurs worldwide and yet there is still no concrete approach in curbing such predicament. The development of related studies especially on pharmacological interventions seems to be decelerated could be due to the lack of interest from the researchers or profit gained from this population. Patients with SUD are more than always received stigmas and negative perceptions form the community they lived in or even from the healthcare practitioners where this population has been associated with violence, crime, misbehaviour and threat to the community that impede healthcare delivery towards them.


Scope of Research Activities

  • Evaluation on the actual burden of SUD disease in our country both for illicit (amphetamine, marijuana, ketum, etc) and prescription drugs.
  • Longitudinal evaluation on the outcomes of current treatment approach (patient, community and national level).
  • Investigation on the effectiveness of methadone maintenance therapy (MMT) program in this country as one of the harm reduction approaches.
  • Identification of possible other treatment approach or strategy in the pipeline to be further developed (eg: PK/PD approach /opioid vaccine).
  • Overviewing, proposing and improving current policy regarding SUD.
  • Identify the potential drug target to treat poly-drug addiction using pharmacological approach.
  • Identify potential compounds in local plants that can be developed to treat drug addiction.


Leader and Members

  • Dr Nor Ilyani Mohamed Nazar. (Leader)
  • Dr Che Suraya Haji Mohd Zin.
  • Dr Mohamad Haniki Nik Mohamed.
  • Dr Norny Syafinaz Ab Rahman.
  • Dr Nor Hidayah Mohd Taufek.
  • Dr Irna Elina Ridzwan.
  • Mdm Siti Halimah Bux Shaikh Rahman Bux.
  • Dr Wael Mohamed Yousef Mohamed (KOM)


Post Graduate Students in Masters in Pharmaceutical Sciences

  • Muhamad Nazrin Syafiq b Khairi - Pharmacy Practice
  • Aida Roziana bt Ramlan - Pharmacy Practice
  • Maryam Saadah bt Suhaimi - Pharmacology
  • Nur Syafinaz bt Wasli - Pharmacology


Laboratory(s) and facility(s)

Conditioned Place Preference Chamber (for rodents’ model) Conditioned Place Preference Chamber (for zebrafish’ model)


Link and Collaboration

  • KOMITED Malaysia
  • SOLACE Malaysia
  • National Anti Drug Agency
  • Jabatan Kesihatan Negeri Pahang
  • University Malaya Centre for Addiction Science (UMCAS)
  • Fakulti Perubatan Universiti Kebangsaan Malaysia


Community Services

  • Students’ visit and service to the centres through Drug Abuse Course.
  • Providing educational and training module on SUD.
  • Providing educational and training module to NADA personnel (knowledge transfer). 


Research Grant

  • RAGS/1/2014/SKK02/UIAM//1 (80,000) 

 A feasibility study of a clinical trial protocol for the administration of ibogaine as an anti-addictive treatment in patients with opioid use disorder.

  • RAGS12-025-0025 (RM40,000) 

Sintesis analog dan modifikasi struktur mitragynine untuk mengkaji perkaitan di antara stuktur mitragynine dengan kesan psikoaktif drug.

  • FRGS14-149-0390 (RM89,000) 

Synthesis and Mechanistic Evaluation of Orvinol Analogues as Potential Anti-Relapse to Morphine/ Methamphetamine Dependence

 

List of Selected Publications 

  • Nor Ilyani Mohamed Nazar. “Ibogaine (Iboga tabernanthe) as a potential anti-addictive treatment in the pipeline: A Review”. International Drug Rehabilitation and Prevention Conference 2014. 16th-17th October 2014. Universiti Sains Islam Malaysia, Nilai, Negeri Sembilan.
  • Nasir Mohamad, Rusli Ismail, Nor Ilyani Mohamed Nazar, Soo Choon Tan, Hann Liang Sim, Ilya Irinaz Idrus, Nor Hidayah Abu Bakar  (2012)   Variability of plasma methadone concentration in opiate dependents receiving methadone: a personalised approach towards optimizing dose .  In: Toxicity and drug testing.  Intechopen.com, Rijeka, Croatia, pp. 129-142 . ISBN 9789535100041
  • Nor Ilyani Mohamed Nazar, Hann Liang Sim , Soo Choon Tan, Rusli Ismail, Ramli Musa, Ahmad Zafri Abu Bakar  (2014).    Daily Clinical Dose (D) poorly predicts trough serum methadone concentration (Ctrough) in patients undergo methadone maintenance therapy with good adherence.   International Journal of Pharmaceutical Science and Health Care, 2 (4).  , 0 pp. 1-9.  ISSN 2249-5738
  • Nur Syafinaz Wasli, Irna Elina Ridzwan, Marwan Saad Azzubaidi, Abdul Razak Kasmuri, Qamar Uddin Ahmed, Long Chiau Ming, Nornisah Mohamed (2017). Upregulation of kappa opioid receptor system and its association with relapse to morphine/methamphetamine (poly-drug) addictionResearch Journal of Pharmacy and Technology, 10 (12). , 0 pp. 4488-4550. ISSN 0974-3618.
  • Irna Elina Ridzwan, Nor Akhi Hijriyati Abdul Rahman, Nur Syafinaz Wasli (2017). The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in miceResearch Journal of Pharmacy and Technology, 10 (12). , 0 pp. 4488-4550. ISSN 0974-3618.
  • Irna Elina Ridzwan, Maryam Saadah Suhaimi, Nur Syafinaz Wasli, Abdul Razak Kasmuri, Marwan Saad Azzubaidi, Ridzwan Hashim, Qamar Uddin Ahmed, ...Nornisah Mohamed (2017). Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependenceBritish Journal of Pharmacy, 2 (2). , 0 pp. S21-22S. ISSN 2058-8356.
  • Irna Elina Ridzwan, Muhammad Harith Zulkifli, Nur Syafinaz Wasli, Syed Mohd Syahmi Syd Mohmad Faudzi (2016). Kappa antagonist to prevent drug relapse: does stage in addiction cycle matter?. Proceedings of the Medical Research Symposium & Pacific Partnership in conjunction with Kuantan Research Day 2016 International Medical Journal Malaysia, 15 (Supplement issue). , 0 pp. 67-67. ISSN 1823-4631..
  • Irna Elina Ridzwan, Maryam Saadah Suhaimi, Abdul Halim Muhamad, Ahmad Jamaluddin Al-Qasami Jusoh, Abdul Razak Kasmuri, Nor Ilyani Mohamed Nazar, Ridzwan Hashim (2014). Evaluating the potential of buprenorphine to reduce relapse to morphine/methamphetamine addictionMalaysian Journal of Pharmacy, 1 (11). , 0 pp. 199-199. ISSN 1675-3666..
  • Vinod Kumar, Irna Elina Ridzwan, Stephen M Husbands, Konstantinos Grivas, John W Lewis, Mary J Clark, Claire Meurice, ...Irina Pogozheva (2014). Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinityJournal of Medicinal Chemistry, 57. , 0 pp. 4049-4057. ISSN 0022-2623.
  • Sarah F Cordery, Alistair Taverner, Irna Elina Ridzwan, Richard H Guy, M Begoña Delgado-Charro, Stephen M Husbands, Christopher P Bailey (2014). A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigmAddiction Biology, 19 (4). , 0 pp. 575-586. ISSN 1355-6215.
  • Irna Elina Ridzwan, Mary Clarke, J. Traynor, Stephen M Husbands, Christopher P Bailey (2012). A single compound alternative to A Buprenorphine/Naltrexone combination to prevent relapse to drug addictionBritish Journal of Clinical Pharmacology, 73 (6). , 0 pp. 1004-1004. ISSN 0306-5251.
  • Irna Elina Ridzwan, Maryam Saadah Suhaimi, Abdul Halim Muhamad, Abdul Razak Kasmuri, Nor Ilyani Mohamed Nazar, Ridzwan Hashim, Syed Mohd Syahmi Syd Mohmad Faudzi. Low-Dose Methamphetamine Addiction Induced Opioid Receptor Sensitization in Polydrug-Dependent Mice. Regional Conference on Science, Technology and Social Sciences (RCSTSS 2016). Chapter 59. p613-624. Springer-International





Background

Quality Use of Medicines (QUM) refers to the selection of suitable therapeutic interventions followed by assuring the safe and cost-effective use of medicines. The World Health Organization have identified improved patient safety in healthcare as a priority. Pharmacists, in particular, have a key role in ascertaining the quality of medications used for patients, especially in vulnerable populations and patients with chronic diseases. Our research group is more practice-oriented that covers all aspects of quality use of medicines. The current research involves but not limited to the use of medicines in geriatrics and patients with diabetes, cardiovascular diseases, infectious diseases, and psychiatric illness. 


Scope of Research Activities

  1. To assess the quality of use and prescribing of medicines.
  2. To investigate the barriers and facilitators towards QUM.
  3. To conduct interventional studies to improve QUM.
  4. To promote and assess the awareness towards medication adherence, medicines information sources and health literacy.
  5. To investigate and assess pharmacists’ competencies, education and training related to QUM.



Leader and Members

  • Asst. Prof. Dr. Mohamed Hassan Elnaem (Leader)
  • Asst. Prof. Dr. Muhammad Eid Akkawi
  • Asst. Prof. Dr. Abdul Rahman Fata Nahas
  • Asst. Prof. Dr. Nor Hidayah Mohd Taufek
  • Asst. Prof. Dr. Nor Ilyani Mohamed Nazar
  • Asst. Prof. Dr. Norny Syafinaz Ab Rahman
  • Asst. Prof. Dr. Siti Hadijah Binti Shamsudin
  • Asst. Prof. Dr. Abdulkareem Mohammed Al-Shami
  • Asst. Prof. Dr. Tengku Karmila Tengku Kamil



Post graduate students

Open for recruitment


Laboratory(s) and Facility(s) 

  • Pharmacy practice laboratory and discussion room


Link and Collaboration

  • Department of Pharmacy, IIUMMC.
  • Department of Internal Medicine, Kulliyyah of Medicine, IIUM.
  • Department of Family Medicine, Kulliyyah of Medicine, IIUM.
  • AP. Dr. Hasniza Zaman Huri, Department of Pharmacy, University of Malaya
  • Dr. Noordin Othman, QUMPRG, Department of Clinical and Hospital Pharmacy, Taibah University, Saudi Arabia.


Community Services

  • Conduct home-medication review (HMR) for elderly patients Campaign to improve health literacy among the public focusing on cardiovascular disease prevention, diabetes and mental health.


Research Grant

  • Improving the Quality Use of the Prescribed Pharmacotherapy for Patients with Chronic Diseases : A Multifaceted Approach, 2020.
  • Evaluation of the factors associated with lipid-lowering therapy use among patients with type 2 diabetes mellitus and the impact of academic detailing.", 2017.
  • Evaluation of lipid-lowering therapy use among patients with type 2 diabetes mellitus in Pahang”, 2016.
  • Development and Assessment of a Smartphone Application to Help Healthcare Providers Avoid Potentially Inappropriate Prescribing Among Hospitalized Elderly Patients, 2015.


List of Selected Publications

  • Elnaem MH, Nik Mohamed MH, Zaman Huri H, Azarisman SM. Effectiveness and prescription pattern of lipid-lowering therapy and its associated factors among patients with type 2 diabetes mellitus in Malaysian primary care settings. Ther Clin Risk Manag. 2019; 18: 137–145.
  • Akkawi ME, Nik Mohamed MH, Md Aris MA, Does inappropriate prescribing affect elderly patients’ quality of life? a study from a Malaysian tertiary hospital. Qual Life Res. 2019.
  • Akkawi ME, Nik Mohamed MH, Are physicians and clinical pharmacists aware and knowledgeable enough about inappropriate prescribing for elderly patients? Findings from Malaysia. Eur J Hosp Pharm. 2018; 25, e29-e34.
  • Elnaem MH, Nik Mohamed MH, Zaman Huri H, Azarisman SM. Impact of educational outreach intervention on enhancing health care providers’ knowledge about statin therapy prescribing in Malaysian patients with type 2 diabetes mellitus. J Eval Clin Pract. 2018; 24: 521–527.
  • Akkawi ME, Nik Mohamed MH, Influence of hospitalization on potentially inappropriate prescribing among elderly patients in a Malaysian community. Trop J Pharm Res. 2018; 17(1):151-160.
  • Elnaem MMH, Nik Mohamed MMH, Huri HZ, Azarisman SM. Patterns of statin therapy prescribing among hospitalized patients with Type 2 diabetes mellitus in two Malaysian tertiary hospitals. Trop J Pharm Res. 2017; 16: 3005–3011. 
  • Elnaem M, Nik Mohamed M, Huri HZ, Azarisman SM, Elkalmi RM. Statin therapy prescribing for patients with type 2 diabetes mellitus: A review of current evidence and challenges. J Pharm Bioallied Sci. 2017; 9: 80.


Background

Research methodology is the overall plan ‘that shapes our choice and use of particular methods and links them to the desired outcomes’. Qualitative research is complementary in evaluating the in-depth standpoints and diverse opinions of healthcare practitioners on patient safety, patient advocacy and patient centered care. Qualitative research imparts more flexible meaning, generally emerge from stakeholders’ direct experiences either from their daily lives or professional practices. 


Scope of research activities

  1. Rigor in Qualitative Research Instrument
  2. Patient- Centered Care through Action Research
  3. Patient Safety through Social Phenomenological Approach
  4. Cultural Competence in Healthcare through Participatory Action Research
  5. Stakeholders Observation on Quality of Life in Patients having Non-communicable Diseases


Leader and members

  • Asst. Prof. Dr. Shazia Jamshed (Leader)
  • Asst. Prof. Dr. Norny Syafinaz Ab Rahman
  • Asst. Prof. Dr. Abdul Kareem Mohammed Al Shami
  • Assoc. Prof. Dr. Hazrina Hadi
  • Asst. Prof. Dr. May Khin Soe 
  • Asst. Prof. Dr. Abdul Rahman Fata Nahas


Post graduate students

  • Doa’ Kamal
  • Adeel Aslam 
  • Akash Syed


Laboratory(s) and Facility(s)

  • Space (Required)
  • Computer-Desktop (Required)
  • Voice Recorder, Video Recorder, Transcription Software with Foot pedal Transcribe. MAXQDA, Diarium (Available with the leader)


Link and Collaboration

  • Dr Shubashini Gnanasan and Dr Mahmathi Karuppannan, Faculty of Pharmacy (Puncak Alam Campus), Universiti Teknologi MARA Selangor, Malaysia
  • Prof Mohd Makmor Bakry, Fakulti Farmasi, UKM
  • Prof Zaheer Babar, Director Pharmaceutical Policy and Practice Center, Department of Pharmacy, University of Huddersfield, United Kingdom
  • Dr Maryam Farooqui, Pharmacy Practice, Unaizah College of Pharmacy, Qassim University, Buraydah, Saudi Arabia
  • Prof Madeeha Malik, Dir. Pharm Pract, Hamdard University, Islamabad, Pakistan
  • Prof Tazeen Saeed Ali, School of Nursing, Aga Khan University, Karachi, Pakistan


Community Services

  • To disseminate the results of community based participatory action research to participants.
  • To provide feedback to the community through public forum and establish mutually beneficial partnership.


Research Grants

  • RIGS15-097- 0097 Prescribing Patterns and Factors Associated with Compliance to Diabetes Selfcare Behaviors and Glycemic Control Among Pakistani And Malaysian People with Type 2 Diabetes Mellitus
  • Grant Amount 20,000 RM
  • Status-Principal Investigator
  • Duration-15th December 2015-18th September 2017
  • Project ID EDW B 13-086-0971
  • Qualitative and Quantitative analysis of Generic medicines’ perception among future pharmacy practitioners: A nationwide study
  • Grant Amout-20,000 RM
  • Status-Principal Investigator
  • Duration-March 2014-March 2015
  • Project Id No BPharm B01/10-Res (19)2013
  • Attitude of Malaysian Pharmacy Students towards Antibiotic Usage and Resistance Mechanism-A Quantitative Insight
  • Grant Amount- RM 13,800
  • Status-Co Investigator 
  • Duration-July 2013-December 2015


List of Selected Publications

  • Doa Alkhalidi, Shazia Qasim Jamshed, Ramadan Elkalmi, Mirza Rafi Baig, Mohamed Azmi Hassali. General Public Views, Attitudes, and Experiences toward Drug Safety in Dubai, United Arab Emirates: A Qualitative Approach. Pharmacy 2019, 7, 19.
  • Eman Dyab, Ramadan Elkalmi, Siti Halimah Bux, Shazia Qasim Jamshed. Exploration of Nurses’ Knowledge, Attitudes, and Perceived Barriers towards Medication Error Reporting in a Tertiary Health Care Facility: A Qualitative Approach. Pharmacy. 2018; 6(4):120.
  • Atta  Abbas Naqvi, Mohamed Azmi Hassali, Mehwish Rizvi, Ale Zehra, Wajiha Iffat, Abdul Haseeb, Shazia Jamshed. Development and validation of a novel General Medication Adherence Scale (GMAS) for chronic illness patients in Pakistan. Frontiers in Pharmacology doi: 10.3389/fphar.2018.01124 https://www.frontiersin.org/articles/10.3389/fphar.2018.01124/abstract
  • Shazia Qasim Jamshed, Mohammad Jamshed Siddiqui, Bareera Rana, Akshaya Srikanth Bhagavathula. Evaluation of the involvement of pharmacists in diabetes self-care: A review from the economic perspective. Frontiers in Public Health 2018, 6.
  • Sakeena Hameem, Alexandra A. Bennett, Shazia Jamshed, Fahim Mohamed, Dilanthi R. Herath, Indika Gawarammana6 and Andrew J. McLachlan. Investigating knowledge regarding antibiotics and antimicrobial resistance among pharmacy students in Sri Lankan universities BMC infectious diseases 2018 18:1
  • Akash Syed, Saira Azhar, Muhammad Mohsin Raza, Humaira Saeed, Shazia Qasim Jamshed. Knowledge, Attitude and Barriers towards Pharmacovigilance among Physicians and Pharmacists of Abbottabad, Pakistan. Pharmacy 2018, 6 (2), 29.
  • Peter Bai James, Abdulai Jawo Bah, Emmanuel Kamanda Margao, Christian Hanson, John Alimamy Kabba, Shazia Qasim Jamshed. Exploring the Knowledge and Perception of Generic Medicines among Final Year Undergraduate Medical, Pharmacy, and Nursing Students in Sierra Leone: A Comparative Cross-Sectional Approach. Pharmacy 2018, 6(1):3.





Background

Toxicology is an integrated discipline that focuses on effects of xenobiotics to living creatures and environment. The group core strength will be mechanistic toxicology on natural toxins, commonly used herbs and conventional drugs. The group will employ traditional toxicology techniques as well molecular techniques to elucidate mechanism of toxicities. 


Scope of research activities 

i.   Isolation and characterization of venom and toxins.

ii.  Proteomic study of venom and toxins.

iii. Neurotoxicity and cardiotoxicity studies for venom and toxins.

iv.  Nephrotoxicity studies of drug-drug, drug-herbal interactions.


Leader and members

  1. Assoc. Prof. Dr. Abdul Razak Kasmuri.
  2. Asst. Prof. Dr. Muhamad Rusdi Ahmad Rusmili.
  3. Asst. Prof. Dr. Che Anuar Che Muhammad.
  4. Asst. Prof. Dr. Rosazra Roslan.
  5. Asst. Prof. Dr. Nurul Asyiqin Yusof.
  6. Asst. Prof. Dr. Zalikha Ibrahim.


Post graduate students: (as main supervisor)

a. On-going (as main supervisor or chairman)

i. Ph.D students:

  • Asyikin Zulkifli . Thesis title: Pharmacological Characterization of Toxins from Malaysian monocled cobra (Naja kaouthia) and equatorial spitting cobra (Naja sumatrana)

b. Graduated  (as main supervisor or chairman)

 None


Laboratories and facilities

General laboratory at Department of Basic Medical Sciences.

  • Link and collaboration:
  • Prof. Iekhsan Othman (Monash University Malaysia)
  • Dr. Ahmad Khaldun Ismail (UKMMC)
  • Major Dr. Janeyuth Chaisakul (Phramongkutklao College of Medicine, Thailand)
  • Dr. Tri Maharani (Toxinology Society of Indonesia)


Community services

  • Seasonal project depending on jellyfish seasonal and migration pattern in Kuantan water. The focus will be on prevention of serious effect caused by jellyfish sting and application of the correct first aid to victim.
  • Insect bites awareness project to educate local community on insect bites


Research Grant (on going)

  • Characterization of Green Pit Viper Venoms RIGS (17-007-0582)
  • Characterization Of Neuromuscular And Cardiovascular Effects Of Non-conventional Three Finger Toxins From Malaysian Spitting Cobra (Naja sumatrana) Venom (FRGS19-040-0648)


List of selected publications

  • Zainal Abidin SA, Rajadurai P, Chowdhury ME, Ahmad Rusmili MR, Othman I, Naidu R. Cytotoxic, Antiproliferative and Apoptosis‐inducing Activity of L‐Amino Acid Oxidase from Malaysian Calloselasma rhodostoma on Human Colon Cancer Cells. Basic & clinical pharmacology & toxicology. 2018 Nov;123(5):577-88.
  • Charoenpitakchai M, Wiwatwarayos K, Jaisupa N, Rusmili MR, Mangmool S, Hodgson WC, Ruangpratheep C, Chanhome L, Chaisakul J. Non-neurotoxic activity of Malayan krait (Bungarus candidus) venom from Thailand. Journal of Venomous Animals and Toxins including Tropical Diseases. 2018 Dec;24(1):9.
  • Rusmil MR, Othman I, Mohamad CA. The Use of Venom and Venom-Derived Products in Medicine and Cosmetics: the Ethical Issues From Islamic Perspective. International Medical Journal Malaysia. 2018 Apr 2;17.
  • Chaisakul J, Rusmili MR, Hodgson WC, Hatthachote P, Suwan K, Inchan A, Chanhome L, Othman I, Chootip K. A pharmacological examination of the cardiovascular effects of Malayan krait (Bungarus candidus) venoms. Toxins. 2017 Apr;9(4):122.
  • Zainal Abidin S, Rajadurai P, Chowdhury M, Ahmad Rusmili M, Othman I, Naidu R. Proteomic characterization and comparison of Malaysian Tropidolaemus wagleri and Cryptelytrops purpureomaculatus venom using shotgun-proteomics. Toxins. 2016 Oct;8(10):299.



Background

The potential of the domestic pharmaceutical industry has been recognised by the Malaysian government as a strategic industry that should be promoted.  In consistent with this aspiration, the Kulliyyah of Pharmacy, IIUM has designated industrial pharmacy as one of its niche areas to assist in the development of the required human capital and the provision of the relevant new knowledge through research.  One way of promoting high quality research and enhancing good research image of the university is to establish a well-balanced team of researchers through the so-called research clustering.  Hence, the establishment of a research cluster at the Kulliyyah of Pharmacy, which focuses in the area of industrial pharmacy, is the way forward.   

 

Objectives:

  • Form a pool of researchers with diverse expertise enabling complementary researches in pharmaceutical development and production;
  • Promote researches addressing emerging problems in pharmaceutical development and production with the ultimate aim of improving quality of life; and
  • Provide scientific support to fledging pharmaceutical industries through collaborative research and consultation service.


Leader and Members


Post Graduate Students in Masters in Pharmaceutical Sciences

  • Thazin Win (PhD)
  • Rana Samour (PhD)
  • Aina Mardiah bt Sabar (MSc)
  • Nur ‘Abidah Mohamed Nasir (PhD)
  • Shaiqah Mohd Rus (PhD)
  • Hamzeh Al Khatib (PhD)
  • Md. Abul Kalam Azad (Phd)
  • Samah Hamed Abdulrahman Almurisi (Phd)
  • Nur Ain Binti Ayob (Phd)
  • Alallam Batoul (Msc)
  • Luqman Muizzuddin Bin Mohd Rosli (Msc)


Laboratory(s) and facility(s)
Instrumentation Lab, Advanced Drug Delivery (ADD)S Lab, Dosage Design Lab, Animal Cell Culture, Cosmetic Laboratory


 
Link and Collaboration

  • Universitas Muhammadiyah, Jogjakarta
  • Universitas Islam Indonesia, Jogjakarta
  • Alfaisal University (Riyadh, Saudi Arabia)


Community Services

  • Training on Good Manufacturing Practice
  • Hand sanitiser preparation and Distribution Covid 19 (2000 bottles) 16-17 March 2020.


Research Grant

  • Prototype Research Grant Scheme (PRGS-2019) Production of Hydrogel Sheet Containing Centella asiatica (pegaga) for wound healing.
  • Microencapsulation of royal jelly in alginate beads using electrospray: a quality-by-design (QbD) approach. (IRAGS 2018) (RM 20,000)
  • Elucidating the anti-cancer Mechanism of thymoquinone nanoparticles involving the MAPK signaling pathway in zebrafish xenografts of colonic and melanoma cancers. in vitro & in vivo study. (FRGS 2017) (RM 88,400)
  • Prototype development of process analytical technology (PAT) continuous production line for Nigella sativa oil (NSO)-alginate microparticles. (PRGS 2019) (RM 116,000)
  • Reproducible Preparation of Thymoquinone Nanoparticles Using Electrospray. (P-RIGS 2018) (RM 20,000)
  • Black Seed Oil Alginate Beads. (Smart Challenge Fund 2018) (RM 871,750)


List of Selected Publications 

  • Hassani, A., et al., Formulation, Characterization and Biological Activity Screening of Sodium Alginate-Gum Arabic Nanoparticles Loaded with Curcumin. Molecules, 2020. 25(9): p. 2244.
  •  Azad, A.K., et al., Encapsulation of Black Seed Oil in Alginate Beads as a pH-Sensitive Carrier for Intestine-Targeted Drug Delivery: In Vitro, In Vivo and Ex Vivo Study. Pharmaceutics, 2020. 12(3).
  •  Almurisi, S.H., et al., Taste masking of paracetamol encapsulated in chitosan-coated alginate beads. Journal of Drug Delivery Science and Technology, 2020. 56.
  •  Mawazi, S.M., et al., Carbamazepine Gel Formulation as a Sustained Release Epilepsy Medication for Pediatric Use. Pharmaceutics, 2019. 11(10): p. 488.     
  • Wan Salleh, Wan Mohd Nuzul Hakimi and On, Shamsul and Ahmad, Farediah and Mohd Sirat, Hasnah and Bakhtiar, M. Taher and Sarker, Satyajit Dey and Nahar, Lutfun (2020) A new xanthone and a new benzophenone from the roots of Garcinia hombroniana. Phytochemistry Letters, 35. pp. 216-219
  • Ayumi, Rasyidah Ryta and Shaik Mossadeq, Wan Mastura and Zakaria, Zainul Amiruddin and Bakhtiar, M. Taher and Kamarudin, Nadhirah and Hisamuddin, Nadia and Talib, Madihah and Sabar, Aina Mardhiah (2020) Antinociceptive activity of asiaticoside in mouse models of induced nociception. Planta Medica
  • Abdul Mudalip, Siti Kholijah and Abu Bakar, Mohd Rushdi and Jamal, Parveen and Adam, Fatmawati (2019) Prediction of mefenamic acid solubility and molecular interaction energies in different classes of organic solvents and water. Industrial & Engineering Chemistry Research, 58 (2). pp. 762-770. ISSN 0888-5885
  • Akanda, Md Jahurul Haque and Sarker, Md. Zaidul Islam and Beh, Leykey and Sharifuddin, Md Shaarani and Siddiquee, Shafiquzzaman and Mamat, Hasmadi and Sahena, Ferdosh and Abdul Hamid, Mansoor and Lee, J. S. and Jinap, Selamat(2019) Valuable components of bambangan fruit (Mangifera pajang) and its co-products: a review. Food Research International, 115. 105 -115. ISSN 0963-9969
  • Hassan, Syajaratul Jahriah and Adam, Fatmawati and Abu Bakar, Mohd Rushdi and Abdul Mudalip, Siti Kholijah (2019)Evaluation of solvents’ effect on solubility, intermolecular interaction energies and habit of ascorbic acid crystals. Journal of Saudi Chemical Society, 23 (2). pp. 239-248. ISSN 1319-6103
  • Jaswir, Irwandi and  Dedi Noviendri and Bakhtiar, Muhammad Taher and Mohamed, Farahidah and Octavianti, Fitri andLestari, Widya and Mukti, Ali Ghufron and Nirwandar, Sapta and Almansori, Bubaker B. Hamad (2019) Optimization and formulation of Fucoxanthin-Loaded Microsphere (F-LM) using Response Surface Methodology (RSM) and analysis of its fucoxanthin release profile. Molecules, 24 (5). pp. 1-16. ISSN 1420-3049
  • Syed Hassan, Sharifah Sariah and Adam, Fatmawati and Abu Bakar, Mohd Rushdi and Abdul Mudalip, Siti Kholijah (2019)Evaluation of solvents’ effect on solubility, intermolecular interaction energies and habit of ascorbic acid crystals. Journal of Saudi Chemical Society, 23 (2). pp. 239-248. ISSN 1319-6103
  • Ab Ghani, Salinda and Abu Bakar, Noor Fitrah and Abu Bakar, Mohd Rushdi and Yusof, Yus Aniza and Abdul Rahman, Norazah (2018) Granulation of mefenamic acid and poly-ethylene glycol (PEG) using pressure swing granulation (psg) technique in fluidized bed [Pembentukan granul berasaskan asid mefenamik dan polietilena glikol (PEG) menggunakan teknik pengranulan tekanan terayun dalam turus terbendalir]. Malaysian Journal of Analytical Sciences, 22 (2). pp. 318-325. ISSN 1394-2506
  • Ab. Hadi, Hazrina and Abdullah, Nurul Shazwani and Ahmed, Qamar Uddin (2018) Exploring the tropical plant wealth: skin and health benefits. In: Current issues in pharmacy. IIUM Press, International Islamic University Malaysia, pp. 149-174. ISBN 9789674184544
  • Ab. Hadi, Hazrina and Azillah, Nurul Namira and Ahmed, Qamar Uddin (2018) Microsponge: a potential delivery system for salicylic acid in treating acne. In: Current issues in pharmacy. IIUM Press, International Islamic University Malaysia, pp. 127-148. ISBN 9789674184544
  • Ab. Hadi, Hazrina and Azman, Amirah (2018) A step forward to develop pharmacist with cosmeceutical knowledge in community pharmacy setting: a pilot study. In: 4th International Pharmaceutical Research Conference 2018, 25th-26th August 2018, Cyberjaya, Malaysia. (Unpublished)
  • Ab. Hadi, Hazrina and Razak, Luqman (2018) Effects of smoking on skin conditions: in vivo assessment. In: 4th International Pharmaceutical Research Conference 2018, 25th-26th August 2018, Cyberjaya, Malaysia. (Unpublished)
  • Ab. Hadi, Hazrina and Zamery, Muhammad 'Izzuddin and Zaiter, Ahmad (2018) Cosmeceutical applications of clay minerals: a review. In: Current issues in pharmacy. IIUM Press, International Islamic University Malaysia, pp. 275-296. ISBN 9789674184544
  • Abdul Kalam, Azad and Doolaanea, Abd Almonem and Al-Mahmood, Sinan Mohammed Abdullah and Wan Sulaiman, Wan Azizi and Al-Ani, Imad Matloub Dally (2018) Microencapsulation of peppermint oil using an ionic gelation electrospray technique. In: 4th International Pharmaceutical Research Conference 2018, 25th-26th August 2018, Cyberjaya, Malaysia. (Unpublished)
  • Abdul Latif, Nurul Hazwani and Bakhtiar, M. Taher and Md Jaffri, Juliana and Amri, Mohamad Shahreen and Abdul Kudos, Muhammad Badri and Wan Sulaiman, Wan Mohd Azizi and Darnis, Deny Susanti (2018) Selected natural agents used for cholesterol controls. Nutrition & Food Science, 48 (2). pp. 301-317. ISSN 0034-6659
  • Abdul Mudalip, Siti Kholijah and Abu Bakar, Mohd Rushdi and Jamal, Parveen and Adam, Fatmawati and Che Man, Rohaida and Sulaiman, Siti Zubaidah and Mohd Arshad, Zatul Iffah and Md. Shaarani, Shalyda (2018) Effects of solvents on polymorphism and shape of mefenamic acid crystals. In: Malaysia Technical Universities Conference on Engineering and Technology (MUCET 2017)., 6-7 Dec,2017, Penang.


Background

Big data in healthcare refers to electronic health data sets that are so large and complex that it would be difficult to manage and analyze using traditional software and data management tools and methods. Big data in healthcare is also known as large health care databases which is one of the sources for drug utilization study. It is often used to address research questions on drug use and drug effect such as evaluation of the processes of prescribing, dispensing and consumption of medicines to improve the quality use of medicines in populations.

Large healthcare databases, which contain data collected during routinely delivered healthcare to patients, can serve as a valuable resource for generating actionable evidence to assist in medical and healthcare policy decision-making. The sources of large healthcare data include electronic medical records, health insurance claims and patient registries. Data may be collected on drug sales, prescriptions, drug distribution chain, pharmaceutical and medical billing. The scope of the databases may be international, national or local. The databases may be diagnosis-linked or non-diagnosis-linked. Diagnosis-linked data enable drug use to be analyzed according to patient characteristics, therapeutic groups, diseases or conditions and, in the best of cases, clinical outcome. A useful analysis requires an understanding of the sources and organization of the data.

Harnessing the power of information contained in large healthcare databases, while paying close attention to their inherent limitations, is critical to generate rigorous evidence-base for medical decision-making and ultimately enhancing patient care.

 

Scope of Research Activities

  1. Data mining for healthcare database study.
  2. Patient level drug utilization.
  3. Advance statistical methods.
  4. Modeling for clinical outcomes.


Leader and Members

  • Assoc. Prof. Dr. Che Suraya Binti Mohd Zin (Leader).
  • Asst. Prof. Dr. Nor Hidayah Mohd Taufek.
  • Asst. Prof. Dr. Nor Ilyani Mohamed Nazar.
  • Asst. Prof. Dr. Norny Syafinaz Ab Rahman.
  • Mdm Nor Elina Alias.


Post graduate students

  • Hosam Jabar, PhD.
  • Asween Rowena, PhD. 
  • Nor Elina Alias, PhD.

Laboratory(s) and Facility(s) 

  • STATA


Link and Collaboration

  • My Health Data Warehouse (MyHDW).
  • Pharmacy and Medical Databases Hospital Selayang and Hospital Sultanah Nur Zahirah.
  • Professor Lisa Nissen, The Queensland University of Technology, Australia.
  • Professor Patrick Ball, The University of Wolver Hampton, United Kingdom.

Community Services

  • Not applicable.


Research Grant

  • FRGS 19 0100618  RM 126500 Pattern analyzer on concomitant use of opioid and benzodiazepine in patients with chronic non-cancer pain: The rising of opioid overdose death (Principal researcher).
  • FRGS 15 1950436  RM114000 Predicting the long term effects and the risks of abuse and misuse in long term opioid users with chronic non-cancer pain (Principal researcher).


List of Selected Publications

  • Zin, Che Suraya, Mohamed Nazar, Nor Ilyani, Ab Rahman, Norny Syafinaz   Ahmad, Wan Rohaidah and   Ng, Kim Swan and  (2019) Patterns of initial opioid prescribing and its association with short and long-term use among opioid naïve patients in Malaysia: a retrospective cohort study. BMJ Open (Revision) (ISI indexed impact factor 2.4)
  • Zin, Che Suraya, Alias, Nor Elina, Tuafek, Nor Hidayah and Ahmad, Mazlila Meor (2019)  Sex Differences in High Opioid Dose Escalation among Malaysian Patients with Long Term Opioid Therapy. Journal of Pain Research (Minor revision) (ISI indexed impact factor 2.6)
  • Asween Rowena Sani, Che Suraya Zin, Abdul Hadi Mohamed, Munira Izat, Tan Hung Ling, Ng Kim Swan and Lisa Nissen (2019) Exploration of change in persistence patterns of opioid use among patients with non-cancer and cancer pain over a three-year follow-up period. Journal of Pharmacy Practice and Research (Minor revision) 
  • Zin, Che Suraya and Mohamed Nazar, Nor Ilyani and Ab Rahman, Norny Syafinaz and Alias, Nor Elina and Ahmad, Wan Rohaidah and Rani, Nurul Sahida and Cardosa, Mary Suma and Ng, Kim Swan and Ye, Felicia Loh (2018) Trends and patterns of analgesic prescribing in Malaysian public hospitals from 2010 to 2016 : Tramadol predominately used. Journal of Pain Research, 11. pp. 1959-1966. ISSN 1178-7090 (ISI indexed impact factor 2.6)
  • Mizher, Hussam A,  Zin, Che Suraya,  Abdullah Sani, Asween Rowena, Mohamed, Abdul Hadi, Tan, H Ling and M. Izat, Munira (2018) Adherence to opioid therapy in patients with chronic non-cancer pain attending a pain clinic in Malaysia. Asian Journal of Pharmaceutical and Clinical Research, 11 (Special Issue 3). pp. 4-7. ISSN 0974-2441 (Scopus indexed)
  • Zin Che Suraya, Fadhilah Ismail, Co-prescription of opioid with benzodiazepine and other co-medications among opioid users: Differential in opioid doses. Journal of Pain Research 2017:10 249–257 (ISI indexed impact factor 2.36)
  • Zin Che Suraya, Norny Abdul Rahman; Che Rokiah Ismail, Leong Weng Choy. Dose and Duration of Opioid Use in Patients with Cancer and Noncancer Pain at an Outpatient Hospital Setting in Malaysia. Pain Practice 2016 Sep 27 (ISI indexed impact factor 2.42)
  • Zin Che Suraya,  Li-Chia Chen, Roger D Knaggs (2014). Changes in trends and pattern of strong opioid prescribing in primary care. European Journal of Pain 18 (2014). ISSN 1532-2149 (ISI indexed impact factor 3.2)


Background

Halia Karak (Karak Ginger)/ Bentong is among the best quality and prices ginger in the world. MOU was signed between IIUM and Koperasi Tok Muda Karak Berhad on 2nd of May 2019. Kulliyyah of Pharmacy (KOP) will involve in consultancies and research on the improvement of current downstream products of Koperasi Tok Muda and develop new products from standardized extract powder and essential oil of Karak Ginger. KOP is also very keen to prepare a monograph on Karak Ginger. This collaboration is hope to improvise Waqf Concept on Health product through IIUM Endowment Fund and Kulliyyah Pharmacy, using IKOP Sdn Bhd as manufacturer to produce Karak Ginger range of health products, cosmetics, supplements and ethical pharmaceutical. This products shall be marketed under IIUM Endowment Fund to raise the funds.


The aim of this project is to assist Koperasi Tok Muda Karak cottage herbal industry to produce products for local and import market. This can create employment opportunities and extra income for local residents. KOP will guide this projects in terms of scientific, technical and regulatory matters while still maintaining their “cottage- style” with required facilities. The process of halal certification will also be part of our commitment.


This project is in line with SDG 3 of the university on Good Health and Wellbeing (SDG 9), industry innovation and infrastructure and partnership for the goals (SDG 17). The use of herbal medicines has been an integral part of Malaysian culture. It is effective for common illness, very reliable, efficient, easily accessible and affordable as herbal medicine.


Scope of Research Activities

To Improve Current Products of Koperasi Tok Muda Karak/ S&M
● List of current products - Pickles, Puree, Powder, Tea, Candy,
Training module-
● Packaging, labelling, adulterated, counterfeit, Good Storage Practice, Halal Certification requirement-Halal Logo, preparation of ginger for extraction and essential oil.


To study properties of karak ginger as natural preservatives for food, cosmeceutical and pharmaceutical products.
Products Development & Formulation: Ginger Cream and Ginger Capsule
● Processing the raw materials

● Formulations

● Production prototypes of several finish products

● Manufacturing, Packaging, Registration

● Marketing Plan 5P’s

● Sales


Prepare Protocol for Standardized Extract of Karak Ginger (Extract of Halia powder).

Produce Protocol and Method for extraction of Essential Oil of Karak Ginger.

Formulation for Halia effervescent and mouth dissolving tablets for morning sickness, nausea and vomiting.

Development of Karak Ginger Herbal Monograph in collaboration with Pahang State Development Center.


Leader and Members

Name of Principal Researcher cum Lead Consultant:
Assist. Prof. Dr Siti Hadijah Bt Shamsudin
Department: Pharmacy Practice Department, Kulliyyah of Pharmacy

Name of Co-Researcher cum Consultant:
Asst. Prof. Dr. Norazian binti Mohd Hassan
Department: Pharmaceutical Chemistry Department, Kulliyyah of Pharmacy

Name of Co-Researcher cum Consultant:
Asst. Prof. Dr.Mohd Rushdi Abu Bakar
Department: Pharmaceutical Technology Department, Kulliyyah Pharmacy

Name of Co-Researcher cum Consultant:
Assoc. Prof. Dr. Alfi Khatib
Department: Pharmaceutical Chemistry Department, Kulliyyah of Pharmacy

Name of Co-Researcher cum Consultant:
Asst. Prof. Dr Mohamed Sufian Mohd Nawi
Department: Pharmaceutical Chemistry Department, Kulliyyah of Pharmacy