KULLIYYAH OF PHARMACY

KULLIYYAH OF PHARMACY

Research Groups

Research Groups



Background

Pharmacognosy is a science that focuses on molecules and involves isolation and determination of the structure of pharmacologically active molecules as well as the study of their biosynthesis, including the enzymes and the genes which are involved. It is extended to a big data analysis to connect between bioactivity, metabolites, and drug sources. Our current performance is indicated as follows. 

Scope of Research Activities

  1. Isolation and characterisation of bioactive compounds
  2. Metabolomics
  3. Bioactivity and toxicity studies
  4. Structure-activity relationship studies (SAR)
  5. Protein-ligand interaction studies
  6. Formulation of standardized extract 
  7. Extract enhancement
  8. Quality control

Leader and Members

Post Graduate Students (as Main Supervisor)

a. On-going (as main supervisor or chairman)

i. Ph.D students:

  • Hussam Abdeljaber Ahmed Mizher (G1524417). Thesis title: Investigation of opioids tolerance and its association with blood and cytokine concentration in the plasma of patients with non-cancer pain receiving short and long term opioid therapy for pain management. Chairman: Assoc. Prof. Dr. ABM Helal Uddin.
  • Nipun Tanzina Sharmin (G1710044). Thesis title: Evaluation of anti-diabetic activity of Psychotria malayana Jack leaves and characterization of its bioactive compounds using metabolomics and molecular docking simulation. Supervisor: Assoc. Prof. Dr. Alfi Khatib.
  • Hidayatul Radziah binti Ismawi (G1517424). Ph. D. Medical Science. (KOM). Thesis Title: Post Partum Endothelin – 1 (ET-1) and Hypertensive Disorders of Pregnancy. Supervisor: Assoc. Prof. Dr. A. B. M. Helal Uddin.
  • Mohammed S.M. Saleh (G152524). Thesis title: Phytochemical Profiling of Salak (Salacca Zalacca) Fruits Extracts through Metabolomics Approach and Investigations of their Antidiabetic and Antioxidant Potential In vitro, In silico and In vivo Studies. Supervisor: Asst. Prof. Mohammad Jamshed Siddiqui

ii. Master students:

  • Nur Nadhirah binti Hilmi (G1624744). Thesis Title: Comparison of Volatile Aroma Constituents of Salacca zalacca (Gaertn.) Voss Fruit Extracted by Conventional and Non-Conventional Methods. Supervisor: Assoc. Prof. Dr. Siti Zaiton.
  • Liyana Zafirah Binti Othman (G1623876). Thesis Title: Formulation and Analytical Method Development of Syariah Compliant Sustained Release Gliclazide Tablet. Supervisor: Assoc. Prof. Dr. ABM Helal Uddin.
  • Ahmed Nokhala (G1810281). Thesis Title: Evaluation of α- Glucosidase Inhibitory Activity o f Tetracera scandens Extracts using Metabolomics Approach. Supervisor: Asst. Prof. Mohammad Jamshed Siddiqui.

b. Graduated (as main supervisor or chairman)

i. Ph.D – no.of students:

  • Assoc. Prof. Dr. Siti Zaiton - 2
  • Assoc. Prof. Dr. Alfi Khatib - 2
  • Assoc. Prof. Dr. ABM Helal Uddin - 2
  • Assoc. Prof. Dr. Qamar Uddin Ahmed - 2

ii. Master – no.of students:

  • Assoc. Prof. Dr. Siti Zaiton - 2
  • Asst. Prof Dr. Norazian - 4
  • Assoc. Prof. Dr. Alfi - 2
  • Assoc. Prof. Dr. ABM Helal Uddin - 5
  • Assoc. Prof. Dr. Qamar Uddin Ahmed - 4
  • Asst Prof Dr Mohammad Jamshed - 1
  • Asst. Prof. Dr. Bisha Fathamah Uzir - 2
  • Asst. Prof. Dr. Irna Elina binti Ridzwan - 2

Laboratories and Facilities

a. Laboratories: Analytical and Bioanalytical Research Lab 1, Analytical Chemistry Research Lab 2, Analytical Chemistry Research Lab 3, Medicinal and Organic Chemistry Research Lab, Pharmaceutical Chemistry Lab 2, Tissue Culture Lab, Herbal Lab.

b. Facilities: FTIR, GCMS, Analytical and Preparative HPLC, AAS, UV-Vis

Link and Collaboration

  • MOU with Universitas Islam Indonesia,
  • MOU with Universitas Airlangga
  • MOU with International Medical University (IMU),
  • MOU with Cyberjaya University College of Medical Sciences (CUCMS)
  • MOU with UiTM

Community Services 

Education on Chemistry of Medicinal Plant – target group to IIUM community, government officers via e-buletin

Research Grant (as PI-on going)

  • RIGS16-293-0457. Isolation, Identification and Computational Studies of α-Glucosidase Inhibitors from Clinacanthus nutans (Burm F.) Lindau Leaves Extracts. Amount: RM 20,000.00. PI: Asst. Prof Dr. Zalikha Ibrahim.
  • SP17-002-0264. Analytical and Biological Activity Analysis of Malaysian leeches Saliva Extract of Both Green and Brown Types. BIOPEP Canada Inc. External Overseas grant. Amount :RM 70,000. PI: Assoc. Prof. Dr. A. B. M. Helal Uddin.
  • RIGS16-292-0456. Influence of multiple reaction monitoring (MRM) on the separation of amlodipine and perindopril in pharmaceutical dosage form and plasma..Amount: RM 20,000. PI: Assoc. Prof. Dr. A. B. M. Helal Uddin.
  • SP11-003-0071. Analytical method development for the detection and determination of amlodipine in pharmaceutical raw materials and dosage forms. Special fund from Ministry of Finance (MOF) Malaysia. Amount:RM 512,000. PI: Assoc. Prof. Dr. A. B.M. Helal Uddin.
  • RIGS15-090-0090. Addressing Formulation Issues of Syariah Compliant Generic Sustained Release Antidiabetic Solid Dosage Form. Co Researcher. IIUM Amount: RM 28,000. PI: Asst. Prof. Dr. Mohamed Sufian Bin Mohd Nawi.
  • P-RIGS18-027-0027. Identification of alpha-glucosidase inhibitors from P. malayana leaf extract using liquid chomatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking. Amount: RM 20,000. PI: Assoc. Prof. Dr. Alfi Khatib.
  • RIGS 15-099-0099. Isolation of Alpha-Glucosidase Inhibitor and aroma from the Flesh of Salak (Salacca zalacca) Fruit and Their Metabolic Profiling on GC/MS. Amount:20,000. PI: Asst. Prof. Dr. M. Jamshed Siddiqui.

List of Selected Publications (1 selected publication for 1 lecturer)

  • Opeyemi Roheem, Fatimah and Mat So'ad, Siti Zaiton and Ahmed, Qamar Uddin and Ali Shah, Syed Adnan and Latip, Jalifah and Zakaria, Zainul
  • Amiruddin (2019). Evaluation of the enzyme inhibitory and antioxidant activities of Entada spiralis stem bark and isolation of the active constituents. Molecules. ISSN 1420-3049
  • Md. Mahmudul Hasan, Qamar Uddin Ahmed, Siti Zaiton Mat Soad, Tasnuva Sarwar Tunna. (2018). Animal models and natural products to investigate in vivo and in vitro antidiabetic activity. Biomedicine & Pharmacotherapy Vol. 101: 833-841.
  • Muhamad Faris, O., Norazian, M. H., Alfi, K. & Siti Marponga, T. (2018). Antioxidant activities of Dialium indum L. fruit and gas chromatography-mass spectrometry (GC-MS) of the active fractions. Antioxidants, 7(11). 1-14. ISSN 2076-3921.
  • Murugesu, S., Ibrahim, Z., Qamar Uddin Ahmed, Uzir, B. F., Yusoff, N. I. N., Perumal, V., ... & Khatib, A. (2018). Identification of α-glucosidase inhibitors from Clinacanthus nutans leaf extract using liquid chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking. Journal of Pharmaceutical Analysis (In Press).
  • Ibrahim, Z., Tejo, B. A., Latif, M. A. M., Karjiban, R. A., Salleh, A. B. and Rahman, M. B. A. (2016). In-silico Identification of Potential Protein Arginine Deiminase IV (PAD4) Inhibitors, Malaysian Journal of Analytical Sciences, 20 (6), 1269-1277.
  • A.B.M. Helal Uddin, Mohamed Alaama, Mohamed b. Awang and S.A. Abbas (2018). Development and Validation of Bioanalytical Method for the Analysis of Amlodipine in Human Plasma with Optimized Extraction Method Using Design of Experiment. Latin American Journal of Pharmacy. Lat. Am. J. Pharm. 37 (1): 99-104. (ISI)
  • Suganya Murugesu, Zalikha Ibrahim, Qamar Uddin Ahmed, Nik Mohd. Idris Nik Yusoff, Bisha Fathamah Uzir, Vikneswari Perumal, Faridah Abas, ...Hesham El-Seedi (2018). Characterization of αglucosidase inhibitors from clinacanthus nutans lindau Llaves by gas chromatography-mass spectrometry-based metabolomics and molecular docking simulation. Molecules, 23 (9). , 0 pp. 1-21. ISSN 1420-3049
  • Hariono, M., Choi, S. B., Roslim, R. F., Nawi, M. S., Tan, M. L., Kamarulzaman, E. E., Mohamed, N., Yusof, R., Othman, S., Rahman, N. A., Othman, R., Wahab, H. A. (2019). Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling. PLoS ONE, 14 (1). , 0 pp.  1 -21. ISSN 1932-6203.
  • Mohammed S M Saleh, Dzatil Awanis Mohd Bukhari, Mohammad Jamshed Ahmad Siddiqui, Abdul Razak Kasmuri, Suganya Murugesu, Alfi Khatib (2019). GC-MS analysis of metabolites from soxhlet extraction, ultrasound-assisted extraction and supercritical fluid extraction of Salacca zalacca flesh and its alpha-glucosidase inhibitory activity. Natural Product Research. , 0 ISSN 1478-641926




Background

Substance Use Disorder (SUD) is a growing public health problem that occurs worldwide and yet there is still no concrete approach in curbing such predicament. The development of related studies especially on pharmacological interventions seems to be decelerated could be due to the lack of interest from the researchers or profit gained from this population. Patients with SUD are more than always received stigmas and negative perceptions form the community they lived in or even from the healthcare practitioners where this population has been associated with violence, crime, misbehaviour and threat to the community that impede healthcare delivery towards them.

Scope of Research Activities

  • Evaluation on the actual burden of SUD disease in our country both for illicit (amphetamine, marijuana, ketum, etc) and prescription drugs.
  • Longitudinal evaluation on the outcomes of current treatment approach (patient, community and national level).
  • Investigation on the effectiveness of methadone maintenance therapy (MMT) program in this country as one of the harm reduction approaches.
  • Identification of possible other treatment approach or strategy in the pipeline to be further developed (eg: PK/PD approach /opioid vaccine).
  • Overviewing, proposing and improving current policy regarding SUD.
  • Identify the potential drug target to treat poly-drug addiction using pharmacological approach.
  • Identify potential compounds in local plants that can be developed to treat drug addiction.


Leader and Members

  • Dr Nor Ilyani Mohamed Nazar. (Leader)
  • Dr Che Suraya Haji Mohd Zin.
  • Dr Mohamad Haniki Nik Mohamed.
  • Dr Norny Syafinaz Ab Rahman.
  • Dr Nor Hidayah Mohd Taufek.
  • Dr Irna Elina Ridzwan.
  • Mdm Siti Halimah Bux Shaikh Rahman Bux.
  • Dr Wael Mohamed Yousef Mohamed (KOM)

Post Graduate Students in Masters in Pharmaceutical Sciences

  • Muhamad Nazrin Syafiq b Khairi - Pharmacy Practice
  • Aida Roziana bt Ramlan - Pharmacy Practice
  • Maryam Saadah bt Suhaimi - Pharmacology
  • Nur Syafinaz bt Wasli - Pharmacology

Laboratory(s) and facility(s)

Conditioned Place Preference Chamber (for rodents’ model) Conditioned Place Preference Chamber (for zebrafish’ model)


Link and Collaboration

  • KOMITED Malaysia
  • SOLACE Malaysia
  • National Anti Drug Agency
  • Jabatan Kesihatan Negeri Pahang
  • University Malaya Centre for Addiction Science (UMCAS)
  • Fakulti Perubatan Universiti Kebangsaan Malaysia

Community Services

  • Students’ visit and service to the centres through Drug Abuse Course.
  • Providing educational and training module on SUD.
  • Providing educational and training module to NADA personnel (knowledge transfer). 


Research Grant

  • RAGS/1/2014/SKK02/UIAM//1 (80,000) 

 A feasibility study of a clinical trial protocol for the administration of ibogaine as an anti-addictive treatment in patients with opioid use disorder.

  • RAGS12-025-0025 (RM40,000) 

Sintesis analog dan modifikasi struktur mitragynine untuk mengkaji perkaitan di antara stuktur mitragynine dengan kesan psikoaktif drug.

  • FRGS14-149-0390 (RM89,000) 

Synthesis and Mechanistic Evaluation of Orvinol Analogues as Potential Anti-Relapse to Morphine/ Methamphetamine Dependence

 

List of Selected Publications 

  • Nor Ilyani Mohamed Nazar. “Ibogaine (Iboga tabernanthe) as a potential anti-addictive treatment in the pipeline: A Review”. International Drug Rehabilitation and Prevention Conference 2014. 16th-17th October 2014. Universiti Sains Islam Malaysia, Nilai, Negeri Sembilan.
  • Nasir Mohamad, Rusli Ismail, Nor Ilyani Mohamed Nazar, Soo Choon Tan, Hann Liang Sim, Ilya Irinaz Idrus, Nor Hidayah Abu Bakar  (2012)   Variability of plasma methadone concentration in opiate dependents receiving methadone: a personalised approach towards optimizing dose .  In: Toxicity and drug testing.  Intechopen.com, Rijeka, Croatia, pp. 129-142 . ISBN 9789535100041
  • Nor Ilyani Mohamed Nazar, Hann Liang Sim , Soo Choon Tan, Rusli Ismail, Ramli Musa, Ahmad Zafri Abu Bakar  (2014).    Daily Clinical Dose (D) poorly predicts trough serum methadone concentration (Ctrough) in patients undergo methadone maintenance therapy with good adherence.   International Journal of Pharmaceutical Science and Health Care, 2 (4).  , 0 pp. 1-9.  ISSN 2249-5738
  • Nur Syafinaz Wasli, Irna Elina Ridzwan, Marwan Saad Azzubaidi, Abdul Razak Kasmuri, Qamar Uddin Ahmed, Long Chiau Ming, Nornisah Mohamed (2017). Upregulation of kappa opioid receptor system and its association with relapse to morphine/methamphetamine (poly-drug) addictionResearch Journal of Pharmacy and Technology, 10 (12). , 0 pp. 4488-4550. ISSN 0974-3618.
  • Irna Elina Ridzwan, Nor Akhi Hijriyati Abdul Rahman, Nur Syafinaz Wasli (2017). The crucial role of nociceptin opioid peptide (NOP) receptor in attenuating relapse to morphine/methamphetamine (poly-drug) addiction in miceResearch Journal of Pharmacy and Technology, 10 (12). , 0 pp. 4488-4550. ISSN 0974-3618.
  • Irna Elina Ridzwan, Maryam Saadah Suhaimi, Nur Syafinaz Wasli, Abdul Razak Kasmuri, Marwan Saad Azzubaidi, Ridzwan Hashim, Qamar Uddin Ahmed, ...Nornisah Mohamed (2017). Distinct role of kappa opioid receptor in attenuating relapse to morphine/methamphetamine (polydrug) dependenceBritish Journal of Pharmacy, 2 (2). , 0 pp. S21-22S. ISSN 2058-8356.
  • Irna Elina Ridzwan, Muhammad Harith Zulkifli, Nur Syafinaz Wasli, Syed Mohd Syahmi Syd Mohmad Faudzi (2016). Kappa antagonist to prevent drug relapse: does stage in addiction cycle matter?. Proceedings of the Medical Research Symposium & Pacific Partnership in conjunction with Kuantan Research Day 2016 International Medical Journal Malaysia, 15 (Supplement issue). , 0 pp. 67-67. ISSN 1823-4631..
  • Irna Elina Ridzwan, Maryam Saadah Suhaimi, Abdul Halim Muhamad, Ahmad Jamaluddin Al-Qasami Jusoh, Abdul Razak Kasmuri, Nor Ilyani Mohamed Nazar, Ridzwan Hashim (2014). Evaluating the potential of buprenorphine to reduce relapse to morphine/methamphetamine addictionMalaysian Journal of Pharmacy, 1 (11). , 0 pp. 199-199. ISSN 1675-3666..
  • Vinod Kumar, Irna Elina Ridzwan, Stephen M Husbands, Konstantinos Grivas, John W Lewis, Mary J Clark, Claire Meurice, ...Irina Pogozheva (2014). Selectively promiscuous opioid ligands: discovery of high affinity/low efficacy opioid ligands with substantial nociceptin opioid peptide receptor affinityJournal of Medicinal Chemistry, 57. , 0 pp. 4049-4057. ISSN 0022-2623.
  • Sarah F Cordery, Alistair Taverner, Irna Elina Ridzwan, Richard H Guy, M Begoña Delgado-Charro, Stephen M Husbands, Christopher P Bailey (2014). A non-rewarding, non-aversive buprenorphine/naltrexone combination attenuates drug-primed reinstatement to cocaine and morphine in rats in a conditioned place preference paradigmAddiction Biology, 19 (4). , 0 pp. 575-586. ISSN 1355-6215.
  • Irna Elina Ridzwan, Mary Clarke, J. Traynor, Stephen M Husbands, Christopher P Bailey (2012). A single compound alternative to A Buprenorphine/Naltrexone combination to prevent relapse to drug addictionBritish Journal of Clinical Pharmacology, 73 (6). , 0 pp. 1004-1004. ISSN 0306-5251.
  • Irna Elina Ridzwan, Maryam Saadah Suhaimi, Abdul Halim Muhamad, Abdul Razak Kasmuri, Nor Ilyani Mohamed Nazar, Ridzwan Hashim, Syed Mohd Syahmi Syd Mohmad Faudzi. Low-Dose Methamphetamine Addiction Induced Opioid Receptor Sensitization in Polydrug-Dependent Mice. Regional Conference on Science, Technology and Social Sciences (RCSTSS 2016). Chapter 59. p613-624. Springer-International




Background

Quality Use of Medicines (QUM) refers to the selection of suitable therapeutic interventions followed by assuring the safe and cost-effective use of medicines. The World Health Organization have identified improved patient safety in healthcare as a priority. Pharmacists, in particular, have a key role in ascertaining the quality of medications used for patients, especially in vulnerable populations and patients with chronic diseases. Our research group is more practice-oriented that covers all aspects of quality use of medicines. The current research involves but not limited to the use of medicines in geriatrics and patients with diabetes, cardiovascular diseases, infectious diseases, and psychiatric illness. 

Scope of Research Activities

  1. To assess the quality of use and prescribing of medicines in healthcare settings.
  2. To describe and assess patterns of medication use and prescribing.
  3. To investigate the barriers and facilitators towards quality use of medicines.
  4. To conduct interventional studies to improve the quality of medication use and prescribing in healthcare settings.
  5. To promote and assess the awareness towards medication adherence, medicines information sources and health literacy.
  6. To investigate and assess pharmacists’ competencies, education and training that deemed necessary to perform their role in the quality use of medicines.

Leader and Members

  • Asst. Prof. Dr. Mohamed Hassan Elnaem (Leader)
  • Assoc. Prof. Dr. Mohamad Haniki Nik Mohamed
  • Asst. Prof. Dr. Muhammad Eid Akkawi
  • Asst. Prof. Dr. Abdul Rahman Fata Nahas
  • Asst. Prof. Dr. Nor Hidayah Mohd Taufek
  • Asst. Prof. Dr. Nor Ilyani Mohamed Nazar
  • Asst. Prof. Dr. Norny Syafinaz Ab Rahman
  • Asst. Prof. Dr. Siti Hadijah Binti Shamsudin
  • Asst. Prof. Dr. Abdulkareem Mohammed Al-Shami
  • Asst. Prof. Dr. Tengku Karmila Tengku Kamil


Post graduate students : open for recruitment

Laboratory(s) and Facility(s) 

  • Pharmacy practice laboratory and discussion room

Link and Collaboration

  • Department of Pharmacy, IIUMMC.
  • Department of Internal Medicine, Kulliyyah of Medicine, IIUM.
  • Department of Family Medicine, Kulliyyah of Medicine, IIUM.
  • AP. Dr. Hasniza Zaman Huri, Department of Pharmacy, University of Malaya
  • Dr. Noordin Othman, QUMPRG, Department of Clinical and Hospital Pharmacy, Taibah University, Saudi Arabia.

Community Services

  • Conduct home-medication review (HMR) for elderly patients Campaign to improve health literacy among the public focusing on cardiovascular disease prevention, diabetes and mental health.

Research Grant

  • Evaluation of the factors associated with lipid-lowering therapy use among patients with type 2 diabetes mellitus and the impact of academic detailing, 20,000 (2017): In Progress
  • Evaluation of lipid-lowering therapy use among patients with type 2 diabetes mellitus in Pahang, 20,000 (2016): completed. 
  • Development and Assessment of a Smartphone Application to Help Healthcare Providers Avoid Potentially Inappropriate Prescribing among Hospitalized Elderly Patients, 20,000 (2015): completed.

List of Selected Publications

  • Elnaem MH, Nik Mohamed MH, Zaman Huri H, Azarisman SM. Effectiveness and prescription pattern of lipid-lowering therapy and its associated factors among patients with type 2 diabetes mellitus in Malaysian primary care settings. Ther Clin Risk Manag. 2019; 18: 137–145.
  • Akkawi ME, Nik Mohamed MH, Md Aris MA, Does inappropriate prescribing affect elderly patients’ quality of life? a study from a Malaysian tertiary hospital. Qual Life Res. 2019.
  • Akkawi ME, Nik Mohamed MH, Are physicians and clinical pharmacists aware and knowledgeable enough about inappropriate prescribing for elderly patients? Findings from Malaysia. Eur J Hosp Pharm. 2018; 25, e29-e34.
  • Elnaem MH, Nik Mohamed MH, Zaman Huri H, Azarisman SM. Impact of educational outreach intervention on enhancing health care providers’ knowledge about statin therapy prescribing in Malaysian patients with type 2 diabetes mellitus. J Eval Clin Pract. 2018; 24: 521–527.
  • Akkawi ME, Nik Mohamed MH, Influence of hospitalization on potentially inappropriate prescribing among elderly patients in a Malaysian community. Trop J Pharm Res. 2018; 17(1):151-160.
  • Elnaem MMH, Nik Mohamed MMH, Huri HZ, Azarisman SM. Patterns of statin therapy prescribing among hospitalized patients with Type 2 diabetes mellitus in two Malaysian tertiary hospitals. Trop J Pharm Res. 2017; 16: 3005–3011. 
  • Elnaem M, Nik Mohamed M, Huri HZ, Azarisman SM, Elkalmi RM. Statin therapy prescribing for patients with type 2 diabetes mellitus: A review of current evidence and challenges. J Pharm Bioallied Sci. 2017; 9: 80.







Background

Research methodology is the overall plan ‘that shapes our choice and use of particular methods and links them to the desired outcomes’. Qualitative research is complementary in evaluating the in-depth standpoints and diverse opinions of healthcare practitioners on patient safety, patient advocacy and patient centered care. Qualitative research imparts more flexible meaning, generally emerge from stakeholders’ direct experiences either from their daily lives or professional practices. 

Scope of research activities

  1. Rigor in Qualitative Research Instrument
  2. Patient- Centered Care through Action Research
  3. Patient Safety through Social Phenomenological Approach
  4. Cultural Competence in Healthcare through Participatory Action Research
  5. Stakeholders Observation on Quality of Life in Patients having Non-communicable Diseases

Leader and members

  • Asst. Prof. Dr. Shazia Jamshed (Leader)
  • Asst. Prof. Dr. Norny Syafinaz Ab Rahman
  • Asst. Prof. Dr. Abdul Kareem Mohammed Al Shami
  • Assoc. Prof. Dr. Hazrina Hadi
  • Asst. Prof. Dr. May Khin Soe 
  • Asst. Prof. Dr. Abdul Rahman Fata Nahas

Post graduate students:

  • Doa’ Kamal
  • Adeel Aslam 
  • Akash Syed

Laboratory(s) and Facility(s)

  • Space (Required)
  • Computer-Desktop (Required)
  • Voice Recorder, Video Recorder, Transcription Software with Foot pedal Transcribe. MAXQDA, Diarium (Available with the leader)


Link and Collaboration

  • Dr Shubashini Gnanasan and Dr Mahmathi Karuppannan, Faculty of Pharmacy (Puncak Alam Campus), Universiti Teknologi MARA Selangor, Malaysia
  • Prof Mohd Makmor Bakry, Fakulti Farmasi, UKM
  • Prof Zaheer Babar, Director Pharmaceutical Policy and Practice Center, Department of Pharmacy, University of Huddersfield, United Kingdom
  • Dr Maryam Farooqui, Pharmacy Practice, Unaizah College of Pharmacy, Qassim University, Buraydah, Saudi Arabia
  • Prof Madeeha Malik, Dir. Pharm Pract, Hamdard University, Islamabad, Pakistan
  • Prof Tazeen Saeed Ali, School of Nursing, Aga Khan University, Karachi, Pakistan

Community Services

  • To disseminate the results of community based participatory action research to participants.
  • To provide feedback to the community through public forum and establish mutually beneficial partnership.

Research Grants

  • RIGS15-097- 0097 Prescribing Patterns and Factors Associated with Compliance to Diabetes Selfcare Behaviors and Glycemic Control Among Pakistani And Malaysian People with Type 2 Diabetes Mellitus
  • Grant Amount 20,000 RM
  • Status-Principal Investigator
  • Duration-15th December 2015-18th September 2017
  • Project ID EDW B 13-086-0971
  • Qualitative and Quantitative analysis of Generic medicines’ perception among future pharmacy practitioners: A nationwide study
  • Grant Amout-20,000 RM
  • Status-Principal Investigator
  • Duration-March 2014-March 2015
  • Project Id No BPharm B01/10-Res (19)2013
  • Attitude of Malaysian Pharmacy Students towards Antibiotic Usage and Resistance Mechanism-A Quantitative Insight
  • Grant Amount- RM 13,800
  • Status-Co Investigator 
  • Duration-July 2013-December 2015

List of Selected Publications

  • Doa Alkhalidi, Shazia Qasim Jamshed, Ramadan Elkalmi, Mirza Rafi Baig, Mohamed Azmi Hassali. General Public Views, Attitudes, and Experiences toward Drug Safety in Dubai, United Arab Emirates: A Qualitative Approach. Pharmacy 2019, 7, 19.
  • Eman Dyab, Ramadan Elkalmi, Siti Halimah Bux, Shazia Qasim Jamshed. Exploration of Nurses’ Knowledge, Attitudes, and Perceived Barriers towards Medication Error Reporting in a Tertiary Health Care Facility: A Qualitative Approach. Pharmacy. 2018; 6(4):120.
  • Atta  Abbas Naqvi, Mohamed Azmi Hassali, Mehwish Rizvi, Ale Zehra, Wajiha Iffat, Abdul Haseeb, Shazia Jamshed. Development and validation of a novel General Medication Adherence Scale (GMAS) for chronic illness patients in Pakistan. Frontiers in Pharmacology doi: 10.3389/fphar.2018.01124 https://www.frontiersin.org/articles/10.3389/fphar.2018.01124/abstract
  • Shazia Qasim Jamshed, Mohammad Jamshed Siddiqui, Bareera Rana, Akshaya Srikanth Bhagavathula. Evaluation of the involvement of pharmacists in diabetes self-care: A review from the economic perspective. Frontiers in Public Health 2018, 6.
  • Sakeena Hameem, Alexandra A. Bennett, Shazia Jamshed, Fahim Mohamed, Dilanthi R. Herath, Indika Gawarammana6 and Andrew J. McLachlan. Investigating knowledge regarding antibiotics and antimicrobial resistance among pharmacy students in Sri Lankan universities BMC infectious diseases 2018 18:1
  • Akash Syed, Saira Azhar, Muhammad Mohsin Raza, Humaira Saeed, Shazia Qasim Jamshed. Knowledge, Attitude and Barriers towards Pharmacovigilance among Physicians and Pharmacists of Abbottabad, Pakistan. Pharmacy 2018, 6 (2), 29.
  • Peter Bai James, Abdulai Jawo Bah, Emmanuel Kamanda Margao, Christian Hanson, John Alimamy Kabba, Shazia Qasim Jamshed. Exploring the Knowledge and Perception of Generic Medicines among Final Year Undergraduate Medical, Pharmacy, and Nursing Students in Sierra Leone: A Comparative Cross-Sectional Approach. Pharmacy 2018, 6(1):3.




Background

Toxicology is an integrated discipline that focuses on effects of xenobiotics to living creatures and environment. The group core strength will be mechanistic toxicology on natural toxins, commonly used herbs and conventional drugs. The group will employ traditional toxicology techniques as well molecular techniques to elucidate mechanism of toxicities. 

Scope of research activities 

i.   Isolation and characterization of venom and toxins.

ii.  Proteomic study of venom and toxins.

iii. Neurotoxicity and cardiotoxicity studies for venom and toxins.

iv.  Nephrotoxicity studies of drug-drug, drug-herbal interactions.

Leader and members

  1. Assoc. Prof. Dr. Abdul Razak Kasmuri.
  2. Asst. Prof. Dr. Muhamad Rusdi Ahmad Rusmili.
  3. Asst. Prof. Dr. Che Anuar Che Muhammad.
  4. Asst. Prof. Dr. Rosazra Roslan.
  5. Asst. Prof. Dr. Nurul Asyiqin Yusof.
  6. Asst. Prof. Dr. Zalikha Ibrahim.

Post graduate students: (as main supervisor)

a. On-going (as main supervisor or chairman)

i. Ph.D students:

  • Asyikin Zulkifli . Thesis title: Pharmacological Characterization of Toxins from Malaysian monocled cobra (Naja kaouthia) and equatorial spitting cobra (Naja sumatrana)

b. Graduated  (as main supervisor or chairman)

 None

Laboratories and facilities

General laboratory at Department of Basic Medical Sciences.

  • Link and collaboration:
  • Prof. Iekhsan Othman (Monash University Malaysia)
  • Dr. Ahmad Khaldun Ismail (UKMMC)
  • Major Dr. Janeyuth Chaisakul (Phramongkutklao College of Medicine, Thailand)
  • Dr. Tri Maharani (Toxinology Society of Indonesia)

Community services

  • Seasonal project depending on jellyfish seasonal and migration pattern in Kuantan water. The focus will be on prevention of serious effect caused by jellyfish sting and application of the correct first aid to victim.
  • Insect bites awareness project to educate local community on insect bites

Research Grant (on going)

  • Characterization of Green Pit Viper Venoms RIGS (17-007-0582)
  • Characterization Of Neuromuscular And Cardiovascular Effects Of Non-conventional Three Finger Toxins From Malaysian Spitting Cobra (Naja sumatrana) Venom (FRGS19-040-0648)

List of selected publications

  • Zainal Abidin SA, Rajadurai P, Chowdhury ME, Ahmad Rusmili MR, Othman I, Naidu R. Cytotoxic, Antiproliferative and Apoptosis‐inducing Activity of L‐Amino Acid Oxidase from Malaysian Calloselasma rhodostoma on Human Colon Cancer Cells. Basic & clinical pharmacology & toxicology. 2018 Nov;123(5):577-88.
  • Charoenpitakchai M, Wiwatwarayos K, Jaisupa N, Rusmili MR, Mangmool S, Hodgson WC, Ruangpratheep C, Chanhome L, Chaisakul J. Non-neurotoxic activity of Malayan krait (Bungarus candidus) venom from Thailand. Journal of Venomous Animals and Toxins including Tropical Diseases. 2018 Dec;24(1):9.
  • Rusmil MR, Othman I, Mohamad CA. The Use of Venom and Venom-Derived Products in Medicine and Cosmetics: the Ethical Issues From Islamic Perspective. International Medical Journal Malaysia. 2018 Apr 2;17.
  • Chaisakul J, Rusmili MR, Hodgson WC, Hatthachote P, Suwan K, Inchan A, Chanhome L, Othman I, Chootip K. A pharmacological examination of the cardiovascular effects of Malayan krait (Bungarus candidus) venoms. Toxins. 2017 Apr;9(4):122.
  • Zainal Abidin S, Rajadurai P, Chowdhury M, Ahmad Rusmili M, Othman I, Naidu R. Proteomic characterization and comparison of Malaysian Tropidolaemus wagleri and Cryptelytrops purpureomaculatus venom using shotgun-proteomics. Toxins. 2016 Oct;8(10):299.